The most common types of IBD includes: ulcerative colitis and Crohn's disease.

The Fecal calprotectin test is widely used as a diagnostic tool to distinguish between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).

All the Calpro`s tests are quantitative methods for the determination of small intestine, large bowel or the stomach in patients, to determine the disease activity and monitor the response to treatment in patients with ulcerative colitis and Crohn`s disease.

Sampling of fecal calprotectin; general advice

In proctitis the area of inflamed mucosa is very limited and the contact time between stool and tissue may be short, especially if the sample is collected late in the day and not from the first defecation. In this situation the intestinal content may pass the short inflamed area very rapidly, not allowing “the incubation time” in the gut to be sufficient for delivery of calprotectin into the stool. This is the reason why it is recommended that samples for calprotectin determination should be collected from the first defecation in the morning, thereby ensuring that “the incubation time” is sufficient. Lasson et al.  studied faecal calprotectin in patients with active ulcerative colitis, samples were collected from consecutive defecations during the day. They found that the levels are highest in samples collected when there is long time between the defecations. It is concluded that the sampling should be the same from day to day, preferably in the morning.



Ulcerative Colitis


SymptomsBloating Cramping Nausea Vomitting Severe Diarrhea Bloodly Stool Abdominal pain Weight Loss FatigueBloating Cramping Nausea Vomitting Severe Diarrhea Bloodly Stool Mocus in Stool Abdomiral pain Weight Loss Higher Likehood of Fistulae Fatigue
ClassificationInflammatory Bowel DiseaseInflammatory Bowel Disease
Possible CausesAutoimmune system of the body attacks the gut, causing inflammation & ulcers on interior all of large intensine. Genetics, bacterial infection or overuse of antibiotics may also play a part.Autoimmune system of the body attacks the gut, causing deep inflammation in the large intestine and possibly small intestine. Genetics, bacterial infection and & or overuse of antibaiotics may also play a part.
PainPain is common in the left part of the abdomenPain is commonly experiencede in lower right abdomen
AppearanceColon wall is thinner and shows continuous inflammation. Mucus lining of large intestine may have ulcers, but they do not extend beyond the inner lining.Colon wall may be thickened and may have rocky appearance. Ulcers along the digestive track are deep and may extend into all layers of the bowel wall.
BleedingBleeding form the rectum during bowel movements.Bleeding from the rectum during bowel movements is not common.
Common TreatmentsDiet Antibiotics Anti-inflammatories Corticosteriods Immunosuppressive Drugs SurgeryDiet Antibiotics Anti-inflammatories Corticosteriods Immunosuppressive Drugs Surgery


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General Information

Fecal calprotectin in differential diagnosis of irritable bowel syndrome

Li XG, Lv YM, Gu F, Yang XL., Department of Gastroenterology, Peking University Third May 9, 2015

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